肠道菌组的变化与冠状动脉疾病的严重程度
Kun An1, Yanxiong Jia1, Boqia Xie1
1Department of Cardiac Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
EBioMedicine
|May 4, 2024
概括
在冠状动脉疾病 (CAD) 患者中,肠道真菌的组成不同. 真菌群落的变化与CAD进展和风险因素有关,这表明真菌是这种心血管疾病的潜在生物标志物.
科学领域:
- 微生物学 微生物学
- 心血管科学 心血管科学
- 人类微生物组研究研究
背景情况:
- 冠状动脉疾病 (CAD) 是导致死亡的主要原因,肠道细菌失衡以前与其发展有关.
- 肠道真菌的作用,肠道微生物群的关键组成部分,在CAD病变发生过程中仍然在很大程度上未被探索.
研究的目的:
- 研究健康个体和患有CAD不同阶段的患者肠道菌群的结构和组成差异.
- 识别特定的真菌种群及其与CAD风险因素和疾病进展的相关性.
主要方法:
- 从132名参与者 (31名健康对照,101名CAD患者) 的便样本分析,使用内部转录间隔器1 (ITS1) 测序用于真菌群体.
- 将CAD患者分为稳定的CAD,不稳定的胸痛和急性心肌梗塞组.
- FUNGuild分析以确定已识别的真菌的生态作用.
主要成果:
- 在所有群体中,Ascomycota和Basidiomycota系的主导地位,而alpha多样性没有显著变化.
- 肠道菌群结构和组成的显著差异与CAD进展相关.
- 鉴定了15种真菌种群,其数量随着疾病发生和进展而变化,与CAD风险因素相关.
- 菌群变化与肠道微生物组失调有关,真菌分类器可以区分CAD子组.
结论:
- 肠道真菌群体的结构和组成在健康对照和CAD亚型之间存在显著差异.
- 特定的真菌种群变化与CAD的发病和进展有关.
- 肠道真菌是开发新生物标志物和CAD治疗策略的潜在领域.
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