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新生儿肠道和免疫反应对小猪的β-素丰富配方
Kristine Holgersen1, Tik Muk2, Mandana Ghisari3
1Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
The Journal of nutrition
|May 4, 2024
概括
婴儿配方中的β-氨酸缩剂高达母乳水平对新生儿是安全的,但过量可能会导致肠道炎症. 在增加β-素时没有观察到额外的肠道成熟益处.
科学领域:
- 新生儿营养新生儿营养
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 贝塔-素是人乳 (HM) 的关键成分,提供对婴儿发育至关重要的生物活性.
- 婴儿配方奶粉通常含有比HM更低的β-素水平,这引发了关于其对婴儿耐受性和成熟度的影响的问题.
研究的目的:
- 评估牛乳婴儿配方中增加β-素含量的临床安全性和潜在益处.
- 在新生儿模型中研究不同度的β-素对肠道和免疫系统成熟的影响.
主要方法:
- 近期的小猪,新生儿的模型,被养四种类型的配方奶粉,具有不同的β-素水平.
- 肠道和免疫参数在第5天进行了死后分析.
- 监测了包括生长,死亡率和腹在内的临床变量.
主要成果:
- 临床结果和大多数肠道参数在标准和中度丰富的β-素配方中是相似的.
- 高水平的β-素 (BCN-高) 与增加的肠道病理,通透性和炎症标志物 (互白素-8) 有关.
- 血淋巴细胞,血栓细胞和网细胞数量的增加,与低氨基细胞的减少,观察到更高的β-素摄入量.
结论:
- 在母乳度的牛奶配方中的β-素丰富在小猪模型中是安全的,但没有提供额外的肠道成熟益处.
- 超过HM水平的过度β-素补充剂可能会诱导肠道炎症并改变血液细胞群.
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