相关实验视频

Updated: Apr 13, 2026

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device

Published on: December 25, 2015

电磁点滴 (DoD) 技术作为无形固体分散生产的创新平台

Abdelrahman M Helmy¹, Anqi Lu², Ishaan Duggal²

¹Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Deraya University, Minya, Egypt.

International journal of pharmaceutics

|May 4, 2024

概括

电磁点滴 (DoD) 3D打印提供了一种新的溶剂蒸发方法,用于创建无形固体分散 (ASD). 这种技术提高了药物溶解度和生物可用性,提高了难溶性药物的生物可用性.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
药物输送系统药物输送系统

背景情况:

无形固体分散 (ASD) 提高了水溶性较差的药物的溶性和生物可用性.
传统的ASD生产依赖于化或溶剂蒸发技术.
需要先进的制造方法来制造ASD.

研究的目的:

引入和评估电磁点滴 (DoD) 技术作为ASD生产的新型溶剂蒸发方法.
为了证明使用多种药物聚合物组合的DoD3D打印生产ASD的可行性.

主要方法:

研究了三种药物聚合物组合: efavirenz-Eudragit L100-55, lumefantrine-hydroxypropyl甲基纤维素酸和favipiravir-多烯酸.
使用电磁按需 (DoD) 3D打印用于ASD制造.
使用偏光显微镜,DSC,XRPD和FTIR光谱学来表征ASD.

主要成果:

通过DoD 3D打印,通过三种药物聚合物组合证实了ASD的形成.
显著增加了 efavirenz (0.03 至 21.18 微克/毫升) 和 lumefantrine (1.26 至 20.21 微克/毫升) 的平衡溶解度.
证明了国防部用于ASD生产的技术的可靠性和有效性.

结论:

电磁DoD3D打印是一种可行的,尖端的溶剂蒸发技术,用于ASD制造.
这项技术有可能实现ASD的按需和连续生产.
国防部的方法提供了一个有前途的替代方案,以提高难以溶解的药物的可溶性.

关键词:

通过3D打印打印3D打印.无形固体分散 (ASD) 是一种在需要时下降 (DoD)药物溶解性药物溶解性药物溶解性埃法维伦兹,卢梅芬特林,法维皮拉维尔

更多相关视频

Generation of Size-controlled Poly ethylene Glycol Diacrylate Droplets via Semi-3-Dimensional Flow Focusing Microfluidic Devices

Generation of Size-controlled Poly ethylene Glycol Diacrylate Droplets via Semi-3-Dimensional Flow Focusing Microfluidic Devices

Published on: July 3, 2018

Glass-Based Devices to Generate Drops and Emulsions

Glass-Based Devices to Generate Drops and Emulsions

Published on: April 5, 2022

相关概念视频

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...