在选择性结直肠癌手术期间,同时对无症状胆结石进行胆囊切除术
Xianda Chi1, Xuejie Li1, Fan Wang2
1Department of Gastrointestinal Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
概括
在结直肠癌 (CRC) 手术期间对无症状胆结石的管理是有争议的. 同时的预防性胆囊切除术减少了随后的胆道并发症,而没有增加手术风险,特别是在老年,患有小多重胆结石的女性患者中.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 胆道医学 胆道医学
背景情况:
- 无症状的胆结石经常在接受结肠直肠癌 (CRC) 手术的患者中发现.
- 这些偶然的胆结石的最佳管理策略仍然是一个临床问题.
研究的目的:
- 评估同时预防性胆囊切除术在无症状胆结石的CRC患者中的安全性和有效性.
- 评估对术后并发症和与胆结石相关的长期疾病的影响.
主要方法:
- 对134名患有无症状胆结石的CRC患者的临床病理学特征和结果的回顾性审查.
- 单独接受选择性结直肠手术的患者 (观察组) 与同时接受胆囊切除术的患者 (胆囊切除组) 之间的结果比较.
- 倾向分数匹配 (PSM) 用于控制混因素.
主要成果:
- 手术后的发病率和死亡率在观察和胆囊切除组之间是相似的.
- 胆囊切除组没有长期的胆道并发症,而观察组在2年内发生了12.4%的发病率.
- 在PSM之后,胆管切除组的长期胆管并发症显著降低 (0.0%对26.5%).
- 观察组中胆道并发症的独立风险因素包括女性性别,年龄≥65,和小的多重胆结石.
结论:
- 在选择性CRC手术期间同时进行预防性胆囊切除术是安全的,不会增加发病率或死亡率.
- 这种方法显著降低了随后与胆结石有关的并发症的风险.
- 预防性胆囊切除术是无症状胆结石的CRC患者的首选选择,特别是老年妇女和具有小多重结石的患者.
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