高压氧气疗法是否可以作为耐火性异常性颗粒性乳腺炎的辅助治疗方法?
Nihan Turhan1, Selin Gamze Sümen2, Taylan Zaman3
1Sancaktepe Martyr Prof.Dr. İlhan Varank Training and Research Hospital, General Surgery, Turkey.
Asian journal of surgery
|May 4, 2024
概括
高压氧气疗法 (HBOT) 是对耐火性IgG4相关疾病 (IGM) 的有效治疗方法,减少类固醇依赖. 需要进一步的前性研究来确认长期的疗效和安全性.
科学领域:
- 医学 医学 医学 医学 医学
- 在瘤学瘤学.
背景情况:
- 耐火性IgG4相关疾病 (IGM) 需要长时间的治疗,包括类固醇和免疫抑制剂,往往导致手术和组织损失.
- 高压氧气疗法 (HBOT) 是慢性伤口的公认治疗方法.
- 研究了HBOT作为耐火性IGM替代疗法的潜力.
研究的目的:
- 评估高压氧气疗法 (HBOT) 作为治疗耐火性IgG4相关疾病 (IGM) 的疗效.
- 为了比较接受标准类固醇治疗的患者与接受HBOT与类固醇治疗相结合的患者之间的结果.
主要方法:
- 从2021年1月到2023年7月,在三个高等保健中心进行了一项回顾性队列研究.
- 耐火性IGM患者被分为两组:仅使用类固醇治疗和联合HBOT和类固醇治疗.
- 分析了人口统计,临床特征,治疗细节和对治疗的反应.
主要成果:
- 两组之间没有发现显著的人口或临床差异,尽管多中心IGM在HBOT组中更为普遍 (p=0.044).
- 恢复结果在各组之间是可比的.
- 仅接受类固醇治疗的患者需要显著更高的平均每日类固醇剂量 (16mg vs. 4mg) 和更长的治疗持续时间 (270天 vs. 30天) (p<0.001).
结论:
- 这项研究表明,HBOT是耐火性IGM的有效治疗方法,有可能减少类固醇依赖.
- 这些发现强调了HBOT作为IGM的新治疗选择.
- 建议进行进一步的前性研究,以评估成本效益和长期并发症.
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