在城市和农村克罗恩病演变研究中的饮食-奥米克 (SOURCE) 队列
Tzipi Braun1, Rui Feng2,3, Amnon Amir1
1Sheba Medical Center, Tel-Hashomer, Affiliated with the Tel Aviv University, Tel Aviv, Israel.
Nature communications
|May 4, 2024
概括
与城市化相关的环境变化推动了克罗恩病 (CD) 的风险. 农村居民搬到城市显示肠道微生物组和代谢物变化反映CD,突出饮食-omics相互作用在疾病的发展.
科学领域:
- 胃肠道学和环境健康
背景情况:
- 克罗恩氏病 (CD) 发病率在全球范围内正在上升,特别是随着城市化.
- 环境因素,而不仅仅是遗传因素,与这种增长有关.
- 城市和农村CD进化研究 (SOURCE) 调查了这些联系.
研究的目的:
- 探索环境暴露,饮食和克罗恩病之间的复杂相互作用.
- 确定在农村到城市过渡期间为CD发展做出贡献的因素.
- 分析饮食学,转录学,代谢学和微生物组数据.
主要方法:
- 具有特征的暴露,饮食,叶转录学,代谢学和微生物组.
- 在农村和城市的中国和以色列的新诊断的CD患者和对照组进行了比较.
- 在SOURCE研究中分析了380名参与者的数据.
主要成果:
- 农村居民在城市环境中度过时间表现出肠道微生物组成和新陈代谢的改变,类似于CD患者.
- 叶转录学揭示了个人代谢和免疫基因表达模块.
- 这些模块与保护性饮食因素 (咖啡,,维生素D),便代谢物和微生物组有关.
结论:
- 城市化相关的环境变化显著影响肠道微生物群和宿主代谢,可能增加克罗恩病风险.
- 饮食因素和微生物代谢物在调节宿主免疫和代谢途径方面发挥着至关重要的作用.
- 了解这些相互作用是制定克罗恩病向干预措施的关键.
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