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在青少年肌细胞性中,动态网络的时空特征的变化

Ming Ke¹, Xiaofei Luo², Yi Guo²

¹School of Computer and Communication, Lanzhou University of Technology, Lanzhou, 730050, China. keming@lut.edu.cn.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|May 4, 2024

概括

青少年肌性 (JME) 患者表现出大脑连接的改变,时间聚类减少,动态功能网络的变化增加. 这些变化,特别是在默认模式和视觉网络中,与症状严重程度相关,可能表明早期疾病障碍.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
的研究研究.

背景情况:

青少年肌性 (JME) 与大脑功能连接 (FC) 的改变有关.
在JME中FC的时空动态尚未完全理解.
动态网络分析提供了对大脑异常和发作机制的见解.

研究的目的:

研究JME患者动态功能连接的时空特征.
为了比较JME患者和健康对照者之间的动态网络特性.
探索动态FC变化与JME症状严重程度之间的关系.

主要方法:

获得了37名JME患者和37名对照者的休息状态功能磁共振成像 (rs-fMRI) 数据.
利用集团独立组件分析 (ICA) 识别了47个用于动态网络构建的网络节点.
在整个大脑,大规模网络和区域层面分析和对比时空特征 (时间聚类,变异性).

主要成果:

在全脑动态网络中,JME患者的时间聚类减少,时间变异性增加.
在默认模式网络 (DMN) 和视觉网络 (VN) 中观察到显著的干扰.
结合性脑脊髓炎的症状严重程度与视觉网络中时间聚类减少相关.

结论:

大脑功能连接的时间动态变化可能会破坏JME中动态大脑网络的时间结构.
在JME网络动态中,DMN和VN至关重要,其异常的时空特性可能是早期疾病功能障碍的潜在原因.
动态网络分析为JME的神经生物学基础提供了宝贵的见解.

关键词:

动态网络的动态网络.功能连接性的功能连接性.功能性网络是指功能性网络.独立的组件分析组件分析青少年肌性 - - 青少年肌性功能磁力共振成像 (fMRI) 是一种

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