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Updated: Jun 27, 2025

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition
09:05

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Published on: August 20, 2016

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转录因子4促进角膜内皮细胞迁移的增加,通过改变Fuchs内皮角膜缩症中的微管

Judy Yan1, Shanti Mehta1,2, Keya Patel1,2

  • 1Sunnybrook Health Sciences Center and Sunnybrook Research Institute, 2075 Bayview Avenue, M-wing, 1st Floor, Toronto, ON, M4N 3M5, Canada.

Scientific reports
|May 4, 2024
PubMed
概括

转录因子4 (TCF4) 在Fuchs内皮角膜缩症 (FECD) 患者细胞中促进细胞迁移. 这发生在表皮-介质细胞过渡的独立性,涉及改变的微管稳定性和TUBB4A上调,表明治疗潜力.

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