在COPD恶化后的前30天内与非致命性心力衰竭和心房或动相关的因素:一个嵌套的病例控制研究
Emily L Graul1, Clementine Nordon2, Kirsty Rhodes2
1School of Public Health, Imperial College London, 86 Wood Lane, London, W12 0BZ, UK.
BMC pulmonary medicine
|May 4, 2024
概括
慢性阻塞性肺病 (COPD) 的严重恶化显著增加了心力衰竭 (HF) 和心房动 (AF) 的住院风险. 年龄,先前的心脏病状况和药物使用是这些恶化后事件的关键相关因素.
科学领域:
- 肺部医学 肺部医学
- 心脏病学 心脏病学
- 临床流行病学临床流行病学
背景情况:
- 在慢性阻塞性肺病 (COPD) 恶化后的第一个月内,存在心力衰竭 (HF) 和心律失常的显著时间风险,特别是心房动/鼓动 (AF).
- 由于HF或AFCOPD后恶化而住院的患者的特定临床特征仍然不清楚.
研究的目的:
- 调查COPD恶化后与HF住院相关的人口和临床因素.
- 为了确定与AF住院相关的因素,在COPD恶化后的30天内.
主要方法:
- 使用英国初级保健电子健康记录 (2014-2020) 进行了两项嵌套病例控制研究.
- 数据链接包括医院病例统计,国家统计局死亡率数据和社会经济数据.
- 使用条件后勤回归分析来确定HF和AF住院的相关因素.
主要成果:
- 随着年龄 (≥80岁),II型糖尿病,肥胖,先前的HF/心律不整史,严重恶化和特定的心血管药物 (例如利尿剂) 的增加,HF住院的风险会增加.
- AF住院风险与年龄较大 (≥80岁),男性性别,严重恶化,先前心律失常/肺高血压史以及某些心血管药物 (例如抗凝剂,内类药物) 相关.
- 严重恶化显示,HF (aOR=6.25) 和AF (aOR=5.78) 住院治疗的关联最强.
结论:
- 心肺因素强烈预测HF住院COPD后恶化.
- 心血管因素和恶化的严重程度是AF在COPD恶化后入院的关键预测因素.
- 识别这些风险因素可以帮助针对高风险个体制定有针对性的预防策略.
关键词:
节律失常 (arrhythmia) 是一种心律失常.在心房动的情况下,心房动.心血管疾病 心血管疾病慢性阻塞性肺病 恶化 恶化电子健康记录电子健康记录流行病学 流行病学飞翔的飞翔 飞翔的飞翔这是心脏衰竭.更多相关视频
08:10Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
1.7K
04:03Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
Published on: September 27, 2024
663
相关概念视频
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
01:20COPD: Pathogenesis and Clinical Features
265
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
265
01:26Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K