紧结蛋白与未接受HIV治疗的人的认知表现之间的关联
Francesca Bai1, Valeria Bono1, Lidia Borghi2
1Clinic of Infectious Diseases.
AIDS (London, England)
|May 5, 2024
概括
艾滋病毒相关的神经认知障碍 (HAND) 在艾滋病毒感染者 (PWH) 中与炎症和血脑屏障 (BBB) 损伤有关. 脑脊液中较低的BBB完整性可能会导致未经治疗的PWH中HAND的发展.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 与艾滋病毒相关的神经认知障碍 (HAND) 仍然是艾滋病毒感染者 (PWH) 的重要关注点.
- 目前尚不完全了解HAND的确切病原体.
- 研究血脑屏障 (BBB) 完整性对于理解HAND发育至关重要.
研究的目的:
- 探索血和脑脊液 (CSF) BBB损伤标志物和未经治疗的PWH中HAND之间的关联.
- 为了确定潜在的生物标志物用于手的发展.
主要方法:
- 涉及未经治疗的PWH的横截面研究.
- 血和脑液标记物的测量:炎症 (IL-15,TNF-α),BBB损伤 (松素,奥克卢丁,克劳丁-5) 和内皮粘附分子 (VCAM-1,ICAM-1).
- 使用综合神经认知电池和弗拉斯卡蒂标准诊断HAND.
主要成果:
- 26.9%的患者呈现HAND (100%无症状神经认知障碍).
- 在HAND患者中,血IL-15水平较高,但脑脊液中松素和奥克卢丁水平较低.
- 多变量后勤回归证实了BBB损伤和HAND之间的关联;内皮粘附分子与认知表现相关.
结论:
- 加剧的炎症和BBB损伤与未经治疗的PWH中HAND有关.
- 失去BBB完整性被认为是导致HAND发展的一个因素.
- 对BBB完整性标记物的进一步研究可能有助于预防和治疗HAND.
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