在不同年龄组接受直肠癌局部与激进切除的患者的生存预后:基于SEER数据库的研究
Jinghui Li1,2,3, Liang Wen1,2,3, Yongli Ma2
1Gannan Medical University, Ganzhou, Jiangxi, China.
Updates in surgery
|May 5, 2024
概括
当地切除 (LE) 为年轻的直肠癌患者提供了比老年患者更好的生存率. 在LE和激光切除 (RE) 之间的生存结果在所有年龄组的直肠癌中都是相似的.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 流行病学 流行病学
背景情况:
- 年龄是影响急性切除 (RE) 后直肠癌预后的关键因素.
- 局部切除 (LE) 是一种替代性手术方法,用于治疗直肠癌.
研究的目的:
- 为了比较不同年龄群体的直肠癌患者的LE和RE之间的生存结果.
- 为了确定与LE治疗的直肠癌中与年龄相关的预后因素.
主要方法:
- 使用SEER数据库对从2010年至2017年接受LE或RE的直肠腺癌患者的回顾性分析.
- 应用了1:1的倾向性得分匹配,以创建可比的LE和RE队列 (每组490名患者).
- 主要终点包括5年总生存率 (OS) 和癌症特异性生存率 (CSS).
主要成果:
- 与66岁以上的患者相比,LE在50岁以下和50-66岁的患者中显示出明显更好的5年OS和CSS.
- 在所有年龄组 (<50,50-66,>66岁) 中,在LE和RE之间没有观察到5年OS和CSS的显著差异.
- 多变量分析确定年龄>66岁,差异化瘤 (III/IV级) 和瘤大小 (3-5厘米) 作为LE后5年OS的独立风险因素.
结论:
- 接受LE治疗的年轻直肠癌患者 (<66岁) 与老年患者 (>66岁) 相比,显示出更高的生存率.
- 手术方法 (LE与RE) 没有显著影响不同年龄组的生存结果.
- 年龄,瘤分化和大小是接受LE的直肠癌患者的关键预后指标.
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