修复的大动脉缩不会影响双大动脉病的四维流量指标
Teemu Kiljander1,2, Petteri Kauhanen3, Saara Sillanmäki2,3
1Department of Cardiology, Tampere University Hospital, Heart Hospital NOVA, Jyväskylä, Finland.
概括
在右左融合型双主动脉 (RL-BAV) 患者中,修复的大动脉缩 (CoA) 并没有显著改变上升大动脉 (AA) 流动力学. 然而,RL-BAV本身与三主动脉相比,大大改变了AA流量.
科学领域:
- 心血管成像 - 心血管成像
- 生物医学工程 生物医学工程
- 遗传性心脏病是一种先天性心脏病.
背景情况:
- 双动脉 (BAV) 是一种常见的先天性心脏缺陷.
- 大动脉缩 (CoA) 经常与BAV有关.
- 了解上升大动脉 (AA) 中的流动动态对于管理这些情况至关重要.
研究的目的:
- 为了比较四维流动MRI (4D流动MRI) 在右-左融合型双主动脉 (RL-BAV) 和修复主动脉缩 (CoA) 的患者上升主动脉 (AA) 的指标.
- 为了比较RL-BAV患者与经过修复的CoA与没有CoA的RL-BAV患者.
- 为了将RL-BAV患者与具有常见三主动脉 (TAV) 的对照组进行比较.
主要方法:
- 11名RL-BAV和CoA患者,11名没有CoA的RL-BAV患者和22名TAV对照患者接受了4D流MRI.
- 在5个AA级别分析了峰值速度,峰值流量和流量位移.
- 在AA的6个部门量化了区域和平均墙壁剪切应力 (WSS) 度量.
主要成果:
- 峰值速度在RL-BAV和CoA组较低,而在近端AA (P=0.047) 没有CoA的RL-BAV则较低.
- 在临近AA (P=0.040) 的RL-BAV和CoA组中,轴向WSS (WSSa,avg) 较高.
- 与TAV对照组相比,RL-BAV患者在大多数AA水平上显示出明显更高的峰值速度和流量位移,远距离平均WSS值更高.
结论:
- 修复的大动脉缩并没有显著改变右左融合型双大动脉的患者上升大动脉四维流量指标.
- 与三主动脉相比,右左融合型双主动脉大大改变了上升主动脉流动的动态.
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