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Afsane Fadaee¹, Fatemeh Sadat Mohammadi², Nazila Ariaee²

¹Faculty of Medicine, Immunology Research Center, Inflammation and Inflammatory Diseases Division, Mashhad University of Medical Sciences, Azadi-Square, Medical Campus, Mashhad 9177948564, Iran; HTLV-1 Foundation, Ghaem Hospital, Mashhad University of Medical Sciences, Ahmad Abad Bolv., Mashhad, Iran.

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概括

大麻素受体 (CBR) 在HTLV-1相关骨髓病变 (HAM/TSP) 中发生变化. 无症状载体中较高的CB1R和CB2R表达表明具有保护作用,可能有利于HAM/TSP患者接受大麻素治疗.

科学领域:

神经免疫学神经免疫学
病毒学病毒学
内类大麻素系统研究研究

背景情况:

人类T淋巴细胞病毒1型 (HTLV-1) 导致炎症性神经退行性疾病HTLV-1-关联骨髓病变 (HAM/TSP).
内分泌大麻素在免疫调节和神经保护中发挥作用,这表明与HAM/TSP病变发生的潜在联系.

研究的目的:

研究HTLV-1调节因子与HAM/TSP中的宿主大麻素受体 (CBR) 之间的相互作用.
在HAM/TSP患者,无症状携带者 (AC) 和健康对照者 (HC) 中评估CB1R和CB2R的基因表达.

主要方法:

在外周血液单核细胞 (PBMC) 中使用RT-qPCR对CB1R和CB2R的基因表达分析.
通过RT-qPCR对HTLV-1前病毒载量 (PVL),Tax和HBZ表达的量化.
对19名HAM/TSP患者,22名AC患者和18名HC患者的基因表达水平进行比较.

主要成果:

与HAM/TSP患者和HC患者相比,AC患者的CB1R表达显著增加.
与HAM/TSP患者和HC患者相比,CB2R基因表达在AC中显著升高.
在HC和HAM/TSP患者中发现CB1R和CB2R基因表达之间的强烈相关性,HAM/TSP患者的HTLV-1税表达更高.

结论:

上调的CB2R可能具有免疫调节作用,而CB1R可能通过抑制ACs中的炎症来提供神经保护,从而可能防止HAM/TSP.
研究结果表明,大麻素药物可能对HAM/TSP具有治疗效益,类似于它们在多发性硬化症 (MS) 中的使用.
进一步研究针对HAM/TSP中内分泌系统的治疗潜力是有必要的.

关键词:

这是一个CB1受体.这是一个CB2受体.大麻素是一种大麻素.HTLV-1相关的骨髓病变/热带性性形.人类T淋巴细胞病毒1

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