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Updated: Jun 27, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Published on: February 16, 2018

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合成和评估白血甲基甲基酸氨基酸酶活性酸酶的二甲基乙烯调节剂A4

Greg Petruncio1, Kyung Hyeon Lee2, Michael Girgis3

  • 1Department of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States; Center for Molecular Engineering, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States.

European journal of medicinal chemistry
|May 5, 2024
PubMed
概括

合成了ARM1的新型阿米诺皮拉 (AMP) 类似物,以激活白血素A4酸酶 (LTA4H) 氨基酶活性. 虽然AMP在体内减少了炎症标志物,但它没有改善生存率,这表明合成基质激活不能保证治疗疗效.

关键词:
氨基酸酶是一种氨基酸酶.酶激活酶的激活方式莱可二烯A(4) 酸酶乌尔曼交叉合器的使用

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