"把它芽":前额叶皮层的低频rTMS破坏了人类威胁记忆的巩固
Simone Battaglia1, Claudio Nazzi2, Miquel A Fullana3
1Center for Studies and Research in Cognitive Neuroscience, Department of Psychology "Renzo Canestrari", Cesena Campus, Alma Mater Studiorum Università di Bologna, 47521, Cesena, Italy; Department of Psychology, University of Turin, 10124, Turin, Italy.
Behaviour research and therapy
|May 5, 2024
概括
在记忆巩固过程中,通过低频重复性横磁刺激 (LF-rTMS) 准背侧前额皮层 (dlPFC),会破坏威胁记忆. 这种干预减少了防御反应,为治疗厌恶性记忆障碍提供了潜力.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 厌恶性记忆巩固还没有完全理解.
- 背侧前额皮质 (dlPFC) 在威胁记忆中的作用尚不清楚.
- 破坏整合可能为创伤相关疾病提供治疗途径.
研究的目的:
- 调查dlPFC在厌恶性记忆巩固中的参与.
- 为了确定低频重复性横磁性刺激 (LF-rTMS) 是否可以破坏威胁记忆的巩固.
- 为了确定dlPFC参与的时间和解剖特异性.
主要方法:
- 采用了差异化的威胁条件范式.
- 在记忆稳定窗口期间,低频重复性横磁性刺激 (LF-rTMS) 针对dlPFC.
- 对照条件包括皮层刺激,延迟dlPFC刺激和假刺激.
主要成果:
- 向的dlPFC LF-rTMS显著降低了对威胁的防御反应,即时,1小时和刺激后24小时.
- 对照条件显示,防御反应没有显著减少.
- 记忆中断效应持续超过了TMS协议的直接抑制窗口.
结论:
- 背侧前额叶皮层 (dlPFC) 在威胁记忆的巩固中具有因果关系.
- 在早期整合过程中选择性地破坏dlPFC活动,防止有条件的威胁响应持续存在.
- 这些发现表明,干扰厌恶性记忆巩固的潜在临床应用.
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