儿科发病多发性硬化症中疾病进展和中枢静脉信号之间的临床相关性:一项双国研究
Shay Menascu1, Simona Halusková2, Amir Pollak1
1Multiple Sclerosis Center, Sheba Medical Center, Ramat-Gan, Israel; Faculty of Medical and Health Sciences, Tel-Aviv University, Israel.
概括
中枢静脉标志 (CVS) 表示儿科发病多发性硬化症 (POMS) 的疾病进展更快. 患有CVS阳性的POMS患者的残疾分数和复发率较高,突出显示CVS阳性.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 儿科 儿科 儿科
背景情况:
- 中枢静脉标志 (CVS) 是一种被提议的MRI生物标志物,用于诊断儿科发病多发性硬化症 (POMS).
- CVS和POMS进展之间的关联仍未得到充分探索.
研究的目的:
- 为了调查POMS患者中CVS的存在.
- 为了确定CVS和POMS疾病进展之间的相关性.
主要方法:
- 来自两个中心的156名POMS患者被跟踪了五年.
- 使用扩展残疾状况尺度 (EDSS) 和年度复发率 (ARR) 评估疾病进展.
- CVS阳性状态被定义为至少40%的脑MRI病变表现出CVS.
主要成果:
- 与CVS阴性患者相比,CVS阳性POMS患者 (38.5%) 在3年和5年的随访中显示出明显更高的EDSS得分.
- 患有CVS阳性的POMS患者表现出明显更高的ARR.
- 这些发现在患有或没有疾病修饰治疗 (DMT) 的患者子组中一致.
结论:
- CVS阳性POMS与更快的残疾进展有关.
- CVS可能在POMS的发病过程中发挥重要作用.
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