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双重的失塑性密码环:管状腺瘤中的新型组织学参数

Carlos A Rubio¹, Michael Vieth², Corinna Lang-Schwarz²

¹Department of Oncology and Pathology, Karolinska Institute, Stockholm 17177, Sweden.

Annals of diagnostic pathology

|May 5, 2024

概括

在超过40%的结肠直肠管状腺瘤 (TA) 中发现了双重的失塑性隐形环 (DCRT). 较大的腺瘤显示DCRT的频率更高,这表明TA的潜在新显微镜标记物.

科学领域:

胃肠病学胃肠病学
病理学病理学病理学
在瘤学瘤学.

背景情况:

在管状腺瘤 (TA) 中,失塑性密室表型的描述有限.
在炎症性肠道疾病 (IBD) 和IBD相关的发育不良症中,已经确定了新的表型,包括双重发育不良性隐形环 (DCRT).

研究的目的:

报告结直肠管状腺瘤 (TA) 中DCRT的发生和频率.
研究DCRT与TA大小,年龄,性别和局部的相关性.

主要方法:

146个连续的结直肠管状腺瘤 (TA) 的分析.
显微镜检查DCRT的存在和数量.
与正常结直肠和非多重性腺瘤的历史对照进行比较.

主要成果:

在146个检查的TA中,40.4% (n=59) 发现了DCRT.
与较小的 (<5毫米) 相比,较大的TA (≥5毫米) 中DCRT的频率显著更高.
没有发现DCRT频率与患者年龄,性别或腺瘤局部之间的相关性.

结论:

DCRT是一种新描述的表型,在显著比例的结直肠管状腺瘤中发生.
TA 尺寸是影响 DCRT 频率的一个关键因素.
对DCRT的进一步研究可能会增强TA的微观表征.

关键词:

科伦·科伦 (Colon Colon) 是指一个结肠.失塑性地的阴间戒指.管状腺瘤是一种管状腺瘤.

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