慢性髓性白血病中的心肌梗塞:来自全国再接收数据库的结果
Elrazi A Ali1, Neel Patel2, Mazin Khalid3,4
1Interfaith Medical Center, One Brooklyn Health, New York, New York, USA.
Oncology
|May 5, 2024
概括
慢性髓性白血病 (CML) 患者的皮肤冠状动脉干预 (PCI) 的结果与非CML患者相似. 接受PCI的CML患者的死亡率和再入院率相似,冠状动脉剖析和缺血性中风的病例较少.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 慢性髓性白血病 (CML) 患者现在由于铁氨酸激酶抑制剂 (TKIs) 的使用,他们的预期寿命有所改善.
- 冠状动脉疾病 (CAD) 正在成为CML幸存者死亡的主要原因.
- 试管婴儿可能会增加心血管事件的风险,包括心肌梗塞.
研究的目的:
- 为了比较通过皮肤冠状动脉干预 (PCI) 在CML患者与没有CML患者的结果.
- 评估住院死亡率,30天再入院率和PCI并发症率.
主要方法:
- 使用全国再接收数据库 (2016-2020) 进行的回顾性队列研究.
- 包括因急性心肌梗塞住院接受PCI的成年人.
- 使用ICD-10代码和倾向性得分匹配来确定患有和没有CML的患者.
主要成果:
- 该研究在2,727,619例心肌梗塞病例中确定了2,124名CML患者;888名CML患者接受了PCI.
- 慢性淋巴瘤患者年龄较大,并患有高血压,糖尿病和先前心血管事件等并发病率较高.
- 在CML和非CML组之间,没有观察到在医院死亡率或30天再入院率的显著差异.
- 虽然整体PCI并发症率相似,但CML患者的冠状动脉剖析和缺血性中风率明显较低.
结论:
- 在CML患者的PCI结局与非CML患者的死亡率和再入院率相似.
- 接受PCI的CML患者可能患上冠状动脉剖析和缺血性中风等特定并发症的风险较低.
- 这表明CML本身或其治疗可能对PCI后的某些不良心血管事件产生保护作用.
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