利博弗拉向的聚合物提高了对帕克利塔塞尔的耐受性,同时保持了治疗疗效
Milita Darguzyte1, Elena Rama2, Anne Rix2
1Institute for Experimental Molecular Imaging, University Hospital Aachen, Forckenbeckstrasse 55, 52074 Aachen, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf, Center for Molecular Medicine Cologne, 50931 Cologne, Germany; Institute for Translational Immune-Oncology, Cancer Research Center Cologne-Essen (CCCE), University of Cologne, 50931 Cologne, Germany.
概括
向黄的药物递送系统 (DDS) 显示了癌细胞吸收的增强和持续的治疗效果. 这种有针对性的方法可以减少化疗.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 积极向提高了药物递送系统 (DDS) 在癌症治疗中的有效性.
- рибофлавин (RF) 是一种具有高癌细胞受体表达的生物相容性联体,适合活性向.
- 帕克利塔塞尔 (PTX) 是一种强效的化疗药物,具有显著的全身毒性.
研究的目的:
- 为了评估射频向的PEG-PTX纳米粒子 (PEG PTX RF) 作为癌症治疗的DDS.
- 为了比较向与非向DDS的疗效和毒性,在体外和体内.
- 评估射频向对药物吸收和治疗结果的影响.
主要方法:
- 合成RF结合的4臂聚乙烯甘醇 (PEG) 恒星与帕克利塔克塞尔 (PTX).
- 在体外细胞毒性测定比较PEG PTX RF,PEG PTX和自由PTX与瘤细胞.
- 在携带瘤的动物体内研究,以评估治疗疗效,瘤扩散和全身毒性.
主要成果:
- 在体外,PEG PTX RF对瘤细胞的毒性比非向PEG PTX的毒性更高.
- 在体内,所有治疗都显示出类似的疗效,但PEG PTX RF导致瘤细胞增殖减少,表明持续的效果.
- 与自由PTX相比,有针对性和非有针对性的DDS减轻了PTX对动物体和肝脏体重的不良影响.
结论:
- 射频向DDS (PEG PTX RF) 有效地将PTX传递给癌细胞,增强药物吸收并使持续的治疗效果成为可能.
- 开发的DDS显著降低了与PTX化疗相关的全身毒性.
- 用RF进行主动准提供了一种有希望的策略,可以提高癌症药物输送的精度和安全性.
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