集成的Janus纳米纤维通过共同溶剂实现,以提高icariin传递效率
Yuhao Sun1, Jianfeng Zhou2, Zhiyuan Zhang2
1Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
International journal of pharmaceutics
|May 5, 2024
概括
研究人员开发了一种新的三通道电方法,以创建用于增强药物输送的Janus纳米结构. 这个系统显著加快了水溶性较差的药物的释放和透,如icariin.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 制药科学 制药科学
背景情况:
- 纳米结构对于开发先进的纳米药物输送系统至关重要.
- 亚努斯纳米结构,有着不同的隔间,为药物封装和释放提供了独特的优势.
研究的目的:
- 开发一种新的三通道旋转网,用于制造Janus纳米结构.
- 在这些Janus纳米结构中研究一种水溶性较差的药物 (icariin) 的封装和释放特性.
- 评估开发的纳米药物输送系统的体外和体外性能.
主要方法:
- 使用定制设计的三通道旋转网和三流体电旋转,制造Janus纳米结构.
- 使用扫描电子显微镜 (SEM) 进行纳米结构的表征.
- 使用富里埃变换红外光谱 (FTIR) 和X射线衍射 (XRD) 分析药物状态.
- 在体外溶解和体外透研究封装的icariin.
主要成果:
- 成功制造了具有两个不同的隔间的线性Janus纳米纤维.
- 由于与基甲基纤维素 (HPMC) 和聚烯 (PVP) 的相互作用,在纳米纤维中验证了伊卡林的无形状态.
- 在5分钟内实现完整的icariin释放 (比原药快11倍).
- 与药物粉相比,伊卡林的透率是药物粉的16.2倍.
结论:
- 开发的三通道电自旋方法对于创建用于药物输送的Janus纳米结构是有效的.
- 雅努斯纳米结构显著增强了水溶性较差的药物的溶解和透.
- 这个平台有望开发各种难溶性化合物的新型纳米药物输送系统.
关键词:
基本的富辛 (PubChem CID: 3081760) 是一个有价值的药物.二甲 (PubChem CID: 6344) 的使用情况药物输送是药物输送的过程.乙醇 (PubChem CID: 24872843) 已经成为一种常见的药物.快速溶解,可以快速溶解.基烯基甲基纤维素 (PubChem CID: 137698383) 的使用情况伊卡里恩是什么意思伊卡里因 (PubChem) CID:329758223) 是一种可以使用的药物.雅努斯纳米结构的纳米结构甲蓝色 (PubChem CID: 6099) 是一种N,N-二甲基形式胺 (PubChem CID: 605365) 是一种聚乙烯罗利 (PubChem CID: 6917) 是一种聚乙烯聚胺.水溶性较差的药物 在水溶性较差的药物侧对侧的电旋转.苏克拉 (PubChem CID: 3654410) 的使用情况相关概念视频
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