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Updated: Jun 27, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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在STAG2突变调节3D基因组组织,染色体循环,和多信号在多形质母细胞瘤

Wanying Xu1, Jung-Sik Kim2, Tianyi Yang1

  • 1Department of Genetics and Genome Sciences, Case Comprehensive Cancer Center, Case Western Reserve School of Medicine, Cleveland, Ohio, USA; The Biomedical Sciences Training Program, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

The Journal of biological chemistry
|May 5, 2024
PubMed
概括

在多种质母细胞瘤 (GBM) 中纠正STAG2突变会改变基因表达和染色质循环. 失去STAG2激活了Polycomb信号,为STAG2突变癌症提供了潜在的治疗标.

关键词:
第二个阶段:第二个阶段大脑瘤是个大脑瘤癌症生物学 癌症生物学在这种情况下,染色染色素染色体结构 染色体结构凝聚力 在凝聚力中基因表达的基因表达方式瘤细胞生物学瘤抑制基因的基因抑制器

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