根据实验和预测的内分泌干扰数据,认可高优先级的消毒副产品:虚拟查和体外研究
Shuxin Sui1, Nan Zhou1, Huihui Liu1
1Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Chemosphere
|May 5, 2024
概括
消毒副产品 (DBPs) 可以破坏内分泌系统,特别是甲状腺. 这项研究优先考虑了DBP,并确定了需要进一步调查其内分泌干扰潜力的特定化合物和组.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 消毒副产品 (DBPs) 是常见的环境污染物.
- 它们的内分泌干扰潜力越来越令人担忧,但特定的高风险化合物仍然不清楚.
研究的目的:
- 识别和优先考虑消毒副产品及其对内分泌干扰潜力最高的组/子组.
- 评估DBP对各种内分泌终点的内分泌干扰作用.
主要方法:
- 更新了1187个DBP的全面列表,分为4个主要组和84个子组.
- 采用虚拟查来优先考虑DBPs,组,子组和内分泌终点.
- 使用体外试验测试对人类转激素 (hTTR) 结合亲和力进行验证的预测.
主要成果:
- 大多数DBP显示出最小的内分泌干扰;甲状腺系统的终点受影响最大 (>10%的活性化合物).
- 芳香型和环型的DBP优先于环型和异环型的DBP.
- 2个子组 (半醇,雌激素DBP) 和23个个别的DBP被列为进一步研究的高优先级.
结论:
- 甲状腺系统是DBP内分泌干扰的关键目标.
- 特定的DBP组 (醇,雌激素DBP) 和单个化合物需要集中研究.
- 实验室验证证实了预测的hTTR结合亲缘关系,支持了查方法.
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