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益生菌补充剂对帕金森病的有效性:系统性审查和元分析

Xiaxia Jin¹, Wendi Dong², Kaile Chang³

¹Chinese Medicine Resource Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Complementary therapies in medicine

|May 5, 2024

概括

益生菌在减轻帕金森病 (PD) 患者的便秘方面表现有希望,通过增加肠道排便和改善生活质量. 需要进一步的研究来证实这些对PD症状的好处.

科学领域:

胃肠病学胃肠病学
神经学神经学
微生物学微生物学

背景情况:

帕金森病 (PD) 是一种神经退行性疾病,经常伴有胃肠道问题,特别是便秘.
便秘显著影响了帕金森病患者的生活质量.

研究的目的:

评估益生菌补充剂在治疗帕金森病中的临床疗效和安全性.
评估益生菌对便症状和PD患者生活质量的影响.

主要方法:

在多个数据库进行了系统的文献搜索,包括PubMed,Embase和Cochrane图书馆,直到2024年1月.
包含756名帕金森病患者的11项随机对照试验 (RCT) 被纳入了元分析.
使用Cochrane偏差风险工具评估研究质量,并使用Review Manager 5.4.4分析数据.

主要成果:

与安慰剂相比,益生菌补充剂显著增加了每周完整肠道排便的数量 (SMD = 0.73,P < 0.00001) 和改善了患者对便秘质量生活问卷评价的得分 (SMD = -0.79,P < 0.001).
在改善便特征或排便努力方面没有观察到显著差异.
益生菌对运动障碍学会-统一-帕金森病评级尺度III分数没有显著影响.

结论:

益生菌显示出作为一种辅助疗法的潜力,可以改善帕金森病患者的便秘.
这些发现支持使用益生菌,单独或与其他治疗结合,用于PD相关的便秘.
建议进行更大,更精心设计的RCT以进一步验证这些结果并探索长期影响.

关键词:

便秘便秘便秘便秘有效性有效性.进行元分析分析.帕金森病是帕金森病的一种.益生菌益生菌益生菌

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