视网膜厚度在第1个月后随机化与以后厚度和视觉敏度的关联在中央静脉封闭中
Ingrid U Scott1, Neal L Oden2, Michael S Ip3
1From the Departments of Ophthalmology and Public Health Sciences (I.U.S.), Penn State College of Medicine, Hershey, Pennsylvania, USA.
American journal of ophthalmology
|May 5, 2024
概括
在抗VEGF治疗后早期视网膜厚度会影响长期结果. 注射后1个月的薄视网膜对视敏度可能与厚视网膜一样有害.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 医疗干预 医疗干预
背景情况:
- 由于视网膜静脉封闭 (RVO) 引起的黄斑是视力丧失的常见原因.
- 抗血管内皮生长因子 (anti-VEGF) 注射,如阿弗利塞普特和贝瓦齐祖马布,是RVO相关的黄斑胀的标准治疗方法.
- 预测治疗反应和长期结果对于管理RVO至关重要.
研究的目的:
- 为了确定第一个抗VEGF注射后1个月的视网膜厚度是否预测了以后的视力敏度,视网膜厚度和治疗需求.
- 分析早期中央子场厚度 (CST) 和眼睛RVO.的后续结果之间的关联.
主要方法:
- 一个队列研究,利用来自对视静脉封闭2 (COAST) 试验的对比治疗研究的数据.
- 分析包括350名参与者,随访2年,评估中央子场厚度 (CST),最佳校正视敏度字母得分 (VALS) 和治疗频率.
- 视网膜被分类为薄 (≤216微米),中等 (>216300微米) 或厚 (>300微米) 基于月1 CST.
主要成果:
- 在第1个月,视网膜被分为薄 (15%),中等 (57%) 或厚 (29%).
- 在第1个月,眼睛的视网膜很薄,在第一年基本保持很薄.
- 在第1个月,视网膜中等的眼睛与视网膜薄的眼睛相比,视力敏度显著提高.
- 厚的视网膜需要最多的治疗,而薄的视网膜需要最少的治疗,特别是在6-24个月之间.
- 薄的视网膜与偏中心急性中间黄斑病变和视网膜内层失调有关.
结论:
- 在抗VEGF治疗后早期视网膜厚度是RVO.长期结果的重要预测因素.
- 在注射后1个月,非常薄的视网膜和非常厚的视网膜都与较差的视力敏度结果有关.
- 这些发现强调了监测早期结构变化的重要性,以指导RVO的治疗策略.
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