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循环代谢物丰度与双极性障碍,精神分裂症和抑郁症风险相关:孟德尔随机化研究
Tianyuan Lu1, Yiheng Chen2, Satoshi Yoshiji3
1Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada; Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada.
欧米茄-3脂肪酸可以降低双相情感障碍的风险,而N-乙氨基酸会增加精神分裂症的风险. 低尿酸显示出潜在的抑郁症. 这些代谢物可能是关键的生物标志物和治疗点.
科学领域:
- 精神病学遗传学和代谢学.
- 调查循环代谢物和精神健康障碍之间的联系.
背景情况:
- 目前对精神疾病的治疗和预防措施有限.
- 循环中的代谢物由于其生物学作用和可测量性,具有作为生物标志物和治疗点的潜力.
研究的目的:
- 评估循环中的代谢物丰度与双相情感障碍,精神分裂症和抑郁症的风险之间的关联,使用孟德尔随机化.
- 确定潜在的生物标志物和精神疾病的治疗点.
主要方法:
- 利用了大规模的全基因组关联研究和孟德尔随机化分析.
- 来自加拿大长度老龄化研究 (N=8299) 的94种代谢物的精选遗传仪器.
- 包括英国生物银行,INTERVAL和EPIC-Norfolk在内的多个队列中的验证结果.
主要成果:
- 基因预测的eicosapentaenoate和docosapentaenoate丰度与双相情感障碍风险降低有关 (ORs为0.72和0.63).
- 增加的欧米茄-3脂肪酸和降低的欧米茄-6和欧米茄-3比率与较低的双相情感障碍风险有关.
- 增加的N-乙氨基酸与更高的精神分裂症风险相关 (OR 1.31).
- 增加的低尿素丰度与抑郁症风险降低有关 (OR 0.85).
结论:
- 欧米茄-3不和脂肪酸,N-乙氨基酸和低尿素需要进一步研究它们在精神疾病中的作用.
- 这些代谢物代表了确定新生物标志物和治疗点的有希望的途径.
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