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在重大抑郁症中,功能连接和代谢的不对称破坏之间的潜在相关性

Yu Yang¹, Haibiao Ye¹, Haohao Yan²

¹Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong 528000, China.

|May 5, 2024

概括

大型抑郁症 (MDD) 与大脑连接的改变以及甲状腺激素和胆固醇水平的异常有关. 这些发现表明,MDD背后可能存在潜在的生物学途径.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
内分泌学在内分泌学.

背景情况:

大型抑郁症 (MDD) 与各种并发症有关,包括胃肠道,甲状腺和代谢问题.
这些并发症和MDD中不对称的功能连接性 (FC) 改变之间的具体关系仍然未得到充分探索.

研究的目的:

调查MDD成年人的非对称功能连接 (FC) 和代谢/甲状腺异常之间的关联.
在MDD患者中探索大脑连接不对称,甲状腺激素水平和血液脂质概况之间的相互关系.

主要方法:

一组42名MDD患者和42名健康对照 (HCs) 接受了临床评估,包括血脂和甲状腺激素水平评估.
休息状态功能磁共振成像 (Rs-fMRI) 用于分析大脑功能连接.
对大脑的功能连接组计算了不对称性参数 (PAS),检查了与临床变量之间的相关性.

主要成果:

与HCs相比,MDD患者的第三代超敏感甲状腺刺激激素 (TSH3UL) 水平明显较低.
在MDD患者的左下额头 (IFG) 和双侧后带状皮质 (Bi-PCC) 中观察到异常不对称.
观察到左侧IFG PAS,TSH和总胆固醇 (CHOL) 之间的初始相关性,但在Bonferroni校正后失去意义.

结论:

患有MDD的患者在前肢体系统中表现出异常的静止状态FC (Rs-FC) 非对称性.
这些不对称可能与MDD中胆固醇和甲状腺激素水平的变化有关.

关键词:

不对称的不对称性胆固醇胆固醇胆固醇非对称性参数的参数休息状态的功能连接.第三代超敏感的甲状腺刺激激素.

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