环境环境和早产的流行病学
Gary M Shaw1, David J X Gonzalez2, Dana E Goin3
1Epidemiology and Population Health, Obstetrics & Gynecology - Maternal Fetal Medicine, Department of Pediatrics, Stanford University School of Medicine, Center for Academic Medicine (CAM), 453 Quarry Road, Stanford, CA 94304, USA.
诸如空气污染和极端高温等环境因素可能会增加早产 (PTB) 的风险. 未来的研究应该考虑暴露组和遗传因素,以全面了解PTB.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 过早出生 (PTB) 是婴儿死亡率和发病率的重要原因.
- 现有的研究往往研究单一的环境暴露,可能缺失的累积效应.
研究的目的:
- 审查个人环境中的环境因素,这些因素可能会影响早产 (PTB) 风险.
- 突出环境暴露与其他PTB风险因素之间的相互作用.
主要方法:
- 对环境环境暴露及其与PTB相关的文献的审查.
- 专注于空气污染物,水污染物,极端高温,工业场所附近,以及绿色空间.
- 考虑修改因素,如社会结构,压力,基因组,表观基因组和饮食.
主要成果:
- 空气污染物,水污染物和极端热量等环境环境暴露与PTB有关.
- 靠近石油/天然气开发和废物场所可能会增加PTB风险.
- 绿色空间的暴露可能会改变PTB风险,可能会产生保护作用.
结论:
- 了解PTB需要检查多次环境暴露 (暴露组) 的累积影响.
- 个体风险是由遗传因素 (基因组,表观基因组),社会压力因素和饮食调节的.
- 考虑暴露组和个体变异性的综合方法对于未来的PTB研究至关重要.
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