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相关概念视频

Ribosome Profiling02:24

Ribosome Profiling

3.5K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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相关实验视频

Updated: Jun 27, 2025

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
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Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

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使用无细胞核糖核酸预测早产

Alison D Cowan1, Morten Rasmussen2, Maneesh Jain3

  • 1Department of Medical Affairs, Mirvie, Inc., 651 Gateway Boulevard, Suite 1200, South San Francisco, CA 94080, USA.

Clinics in perinatology
|May 5, 2024
PubMed
概括
此摘要是机器生成的。

自发早产 (spontaneous preterm birth,sPTB) 是一个复杂且不太了解的疾病,阻碍了预防. 在母体血液中的无细胞RNA签名可以识别sPTB亚型,以进行预测和改善管理.

关键词:
没有细胞的RNA.宫衰竭是发生在宫上的一种疾病.病理起因 病理起因 病理起因预产前期膜的破裂,导致产前期膜的破裂.选模型的选模型自发的早产,即早产.文字转录学 (Transcriptomics) 是一个学科.

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A Rapid High-throughput Method for Mapping Ribonucleoproteins RNPs on Human pre-mRNA
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Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
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A Rapid High-throughput Method for Mapping Ribonucleoproteins RNPs on Human pre-mRNA
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科学领域:

  • 生殖生物学 生殖生物学
  • 基因组学就是基因组学.
  • 孕产妇与胎儿的医学

背景情况:

  • 自发早产 (sPTB) 是新生儿发病率和死亡率的主要原因.
  • 目前尚不完全了解sPTB的潜在生物机制,这限制了有效的预防策略.

研究的目的:

  • 探索在母体循环中的无细胞核糖核酸 (cfRNA) 信号的潜力,用于分类sPTB亚型.
  • 研究cfRNA签名作为预测无症状个体sPTB的生物标志物.

主要方法:

  • 从经历了sPTB的个体的母体血液样本中分析cfRNA概况.
  • 生物信息分析以确定与sPTB亚型相关的独特cfRNA签名.

主要成果:

  • 识别与不同sPTB亚型相关的特定cfRNA特征.
  • 证明cfRNA在分辨早产的各种原因或途径方面的潜力.

结论:

  • 无细胞RNA签名对阐明sPTB的异质性具有前景.
  • 这些生物标志物可以实现早期预测,个性化预后,并针对sPTB和相关疾病进行有针对性的干预.