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相关概念视频

Development of Immunocompetence01:22

Development of Immunocompetence

303
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
303

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相关实验视频

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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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使用免疫基因预测自发早产

Dorien Feyaerts1, Ivana Marić2, Petra C Arck3

  • 1Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA 94305, USA.

Clinics in perinatology
|May 5, 2024
PubMed
概括
此摘要是机器生成的。

流通中的孕产妇免疫动态提供了对妊娠进展的洞察力,并可以预测自发早产 (sPTB). 了解这些免疫变化可能会导致早期风险评估和sPTB的新生物标志物.

关键词:
母亲的血液来自母亲的血液.母亲的免疫系统 母亲的免疫系统多种omics模型的建模.单细胞细胞计是单细胞细胞计.自发的早产,即早产.自发的早产劳动全血转录基因组是全血转录基因组的一个组成部分.

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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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相关实验视频

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科学领域:

  • 免疫学 免疫学 免疫学
  • 生殖生物学 生殖生物学
  • 计算生物学 计算生物学

背景情况:

  • 怀孕涉及复杂的免疫调节,外周循环反映这些变化.
  • 在母胎界面的局部免疫反应会影响系统免疫力.
  • 自发早产 (sPTB) 是一个关键的产科并发症,需要早期预测.

研究的目的:

  • 探索母体免疫动态的潜力,作为预测自发早产 (sPTB) 的预测工具.
  • 为了研究跨组织免疫相互作用在怀孕中的作用.
  • 确定用于早期评估sPTB风险的新生物标志物.

主要方法:

  • 利用系统免疫学方法来分析免疫细胞状态.
  • 检查局部生殖组织与外周循环之间的相互作用.
  • 整合多种生物数据模式进行全面分析.

主要成果:

  • 孕妇的外周循环中含有免疫特征,表明怀孕状态.
  • 在整个妊娠期间,免疫力学受到严格调节.
  • 这些免疫模式与自发早产的风险有关.

结论:

  • 怀孕期间的细胞免疫状态可以作为sPTB的早期预警系统.
  • 系统免疫学和多模式数据集成可以提高对早产的理解.
  • 这项研究有望确定用于sPTB预测的临床可操作的生物标志物.