系统性免疫炎症指数的评估,以预测下肢动脉疾病的严重程度
Ersan Oflar1, Evliya Akdeniz1, Cennet Yıldız1
1Cardiology Department, Bakırkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Vascular
|May 5, 2024
概括
系统性免疫炎症指数 (SII) 可能预测更复杂的下肢动脉疾病 (LEAD). 在患有外周动脉疾病的患者中,较高的SII值与高级TASC C-D分类有关.
科学领域:
- 血管医学 血管医学
- 炎症生物标志物 炎症生物标志物
- 周围动脉疾病 周围动脉疾病
背景情况:
- 系统性免疫炎症指数 (SII) 是炎症和免疫细胞活性的标志物.
- 之前的研究已经证明了SII在冠状动脉疾病和心力衰竭等心血管疾病中的预测价值.
- 在下肢动脉疾病 (LEAD) 中SII的作用仍然不太被探索.
研究的目的:
- 评估在被诊断为下肢动脉疾病 (LEAD) 的患者中系统性免疫炎症指数 (SII) 的预测值.
- 评估SII与LEAD严重程度之间的相关性,根据跨大西洋社会间共识 (TASC II) 标准进行分类.
主要方法:
- 分析了271名LEAD患者的队列.
- 采集了血液样本,以检测全血细胞计和生化变量.
- 系统性免疫炎症指数 (SII) 为每个患者计算.
- 使用TASC II分类来对疾病的严重程度进行分类.
主要成果:
- 发现,患有更严重的LEAD (TASC C-D) 患者的SII值与患有不太严重疾病 (TASC A-B) 患者相比显著更高.
- SII显示了与LEAD严重程度的显著正相关性 (r = 0.363,p < .001).
- 664.24的SII值有效预测了TASC C-D疾病,敏感度为60.8%,特异性为73.3%.
结论:
- 系统性免疫炎症指数 (SII) 升高可能表明较高的复杂下肢动脉疾病 (LEAD) 的概率.
- 这些发现表明,通过SII测量系统性炎症与外周动脉疾病的严重程度之间存在潜在联系.
- 这种关系与冠状动脉疾病和外周动脉疾病之间已知的共享病理生理学一致.
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