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Updated: Jun 27, 2025

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在外部评估人口药理动力学模型时,样本大小,采样策略或处理低于量化下限的度是否重要?

Mehdi El Hassani1,2, Uwe Liebchen3, Amélie Marsot4,5

  • 1Faculté de pharmacie, Université de Montréal, 2940 chemin de Polytechnique, Montréal, QC, H3T 1J4, Canada. mehdi.el.hassani@umontreal.ca.

European journal of drug metabolism and pharmacokinetics
|May 5, 2024
PubMed
概括

对人口药动力学模型的外部评价 (EE) 表明大样本大小是不必要的. 使用治疗药物监测 (TDM) 开发的模型可能更具概括性,并且基于概率的处理量化极限以下的数据可以改善偏差.

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