主观听力损失和认知障碍之间的关联和潜在的多重机制
1Qi-Hao Guo, Department of Gerontology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China, Phone: +86 13817741448, E-mail: qhguo@sjtu.edu.cn; Fang Xie, Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200040, China, Phone: +86 13818672745,
The journal of prevention of Alzheimer's disease
|May 6, 2024
概括
主观听力损失 (SHL) 独立影响认知功能,特别是听觉记忆. 抑郁情绪调解了这种效果,表明了超出常见原因的复杂机制.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 主观听力损失 (SHL) 是一个自我报告的听力能力下降.
- SHL与认知障碍之间的关系需要进一步调查潜在机制.
研究的目的:
- 为了验证将SHL与认知障碍联系在一起的潜在机制.
- 探索情绪,生物标志物和心血管因素在这种关联中的作用.
主要方法:
- 对来自上海的2369名参与者的横截面研究.
- 神经心理学评估包括老年人选版本 (HHIE-S) 的听力障碍清单.
- 收集大脑β-粉样蛋白 (Aβ) 沉积,阿尔茨海默病 (AD) 血生物标志物和心血管风险因素.
主要成果:
- 升高的SHL (HHIE-S得分) 与认知和日常功能差,情绪抑郁增加相关,特别是在听觉记忆中.
- 抑郁情绪调解了SHL对认知的影响.
- SHL与糖尿病和吸烟有关;认知功能与高脂血症和酒精使用有关.
- 在脑Aβ沉积的个体中,SHL与认知的关联独立于AD生物标志物和APOE状态.
结论:
- 主观听力损失对认知障碍有独立的影响.
- 研究结果支持认知资源,贫困的环境和病理相互作用机制,而不是共同的原因.
- SHL对认知的影响是多方面的,需要进一步的机制研究.
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