药物使用的预测者 青春期早期开始使用药物
ReJoyce Green1, Bethany J Wolf1, Andrew Chen1
1Department of Psychiatry and Behavioral Sciences (Green, Kirkland, Browning, Bryant, Tomko, Gray, Squeglia) and Department of Public Health Sciences (Wolf, Chen, Ferguson), Medical University of South Carolina, Charleston; Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia (Mewton).
The American journal of psychiatry
|May 6, 2024
概括
早期青少年开始使用药物与以后的疾病有关. 社会人口统计学因素,而不是复杂的生物测量,最好预测12岁之前的试用物质.
科学领域:
- 青少年发展 青少年发展
- 药物使用障碍 药物使用障碍
- 预测建模的预测建模.
背景情况:
- 早期青少年开始吸毒是以后吸毒和精神健康障碍的风险因素.
- 了解启动的预测因素对于及时干预至关重要.
研究的目的:
- 确定12岁时开始使用物质的强有力的预测因素.
- 评估神经生物学和认知措施在预测物质使用开始方面的附加价值.
主要方法:
- 对6829名未曾吸毒的青少年 (9-10岁) 进行了长度研究,并对其进行了3年的跟踪.
- 研究了人口,心理,健康和神经生物学领域的420个变量.
- 使用有惩罚的逻辑回归与弹性网用于预测建模.
主要成果:
- 14.4%的儿童在12岁时开始使用物质,主要是酒精.
- 社会人口统计学因素是开始使用物质的最强有力的预测因素.
- 添加荷尔蒙,神经认知和神经成像数据并没有显著改善预测准确性 (AUC=0.66).
结论:
- 社会人口统计学变量是识别面临物质使用风险的年轻人最有效的预测因素.
- 资源密集型的生物和神经成像措施不能增强预测模型.
- 调查结果可以在临床环境中为简化预防和早期干预策略提供信息.
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