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Updated: Jun 27, 2025

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托皮拉与纳尔特雷治疗酒精使用障碍:基因型分层双盲随机对照试验

Kirsten C Morley1, Henry R Kranzler1, Natasha Luquin1

  • 1Specialty of Addiction Medicine, Sydney Medical School (Morley, Adams, Montebello, Tremonti, Dali, Logge, Haber), School of Health Sciences (Baillie), and Matilda Centre for Mental Health and Substance Use (Teesson), Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Edith Collins Centre for Translational Research in Alcohol, Drugs, and Toxicology (Morley, Jamshidi, Logge, Haber) and Department of Medical Genomics (Luquin, Trent), Royal Prince Alfred Hospital, Camperdown, Australia; Center for Studies of Addiction, Perelman School of Medicine, University of Pennsylvania, and Mental Illness Research, Education, and Clinical Center, Crescenz VA Medical Center, Philadelphia (Kranzler); Northern Sydney Local Health District Drug and Alcohol Services, St Leonards, Australia (Montebello); St Vincent's Hospital Sydney, Sydney, Australia (Tremonti).

The American journal of psychiatry
|May 6, 2024
PubMed
概括

托皮拉对酒精使用障碍 (AUD) 的有效性和安全性与纳尔德相比,在减少渴望和BMI方面取得了更好的结果. 在这项研究中,遗传多态性没有影响治疗反应.

关键词:
酒精使用障碍 酒精使用障碍希腊 希腊人纳尔特雷克松是一种纳尔特雷克松.在OPRM1中使用OPRM.药物遗传学 药物遗传学托皮拉酸盐是最重要的.

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