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动脉样硬化中的外体:病变发生中的作用和治疗点

Siarhei Dabravolski¹, Vasily N Sukhorukov², Victor Glanz²

¹Department of Biotechnology Engineering, Braude Academic College of Engineering, Snunit 51, P.O. Box 78, Karmiel 2161002, Israel.

Current medicinal chemistry

|May 6, 2024

概括

外体是参与细胞通信的微小囊泡,在动脉样硬化心血管疾病 (ASCVD) 的发展和进展中发挥着重要作用. 了解外体细胞的功能为ASCVD的诊断和治疗提供了潜力.

科学领域:

心血管生物学心血管生物学
细胞和分子医学是细胞和分子医学.
纳米医学是一种纳米医学.

背景情况:

动脉样性心血管疾病 (ASCVD) 是全球死亡的主要原因,其特点是动脉壁重塑和斑块积累.
外体是细胞间通信的关键媒介,在细胞之间运输生物活性分子.
人们越来越认识到外体在动脉样硬化病原体中的复杂作用.

研究的目的:

审查外体生物学及其在动脉样硬化中的多面性作用.
探索来自各种细胞起源的外体对疾病进展的影响.
讨论ASCVD中外体的诊断和治疗潜力.

主要方法:

文献综述侧重于外体生物学和动脉样硬化中的功能.
对研究异构体载体和受体细胞相互作用的研究进行分析.
对ASCVD基于外体的诊断和治疗方法的当前研究进行了审查.

主要成果:

来自不同细胞类型 (内皮细胞,巨细胞,干细胞等) 的外体. 显著影响动脉样硬化发展.
外体介导的细胞间通信影响胆固醇的运输,炎症和受体细胞的亡.
外体体内的微RNA是ASCVD病变发生的关键参与者.

结论:

外体是调节与动脉样硬化相关的各种细胞过程的关键.
外基因组作为ASCVD诊断的生物标志物和治疗剂具有前途.
需要进一步的研究,以克服外体在ASCVD的临床应用中的局限性.

关键词:

动脉样硬化是一种动脉样硬化.心血管疾病心血管疾病外基因组是外基因组的组成部分.这是一种炎症,炎症.这是一个微型RNA.

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