分析和生物分析方法用于在各种矩阵中确定二乙酶-4抑制剂:综合性审查
Sakshi Hadawale1, Sanjay Sharma1
1Department of Quality Assurance, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Deemed to be University, Vile Parle West, Mumbai, Maharashtra, 400056, India.
Current diabetes reviews
|May 6, 2024
概括
双基化酶-4 (DPP-4) 抑制剂,或素,对于2型糖尿病的管理至关重要. 本综述详细介绍了gliptins的分析方法,强调了色谱学,并为未来的研究提出了环保溶剂替代品.
科学领域:
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
- 药用化学 医学化学
背景情况:
- 双基化酶-4 (DPP-4) 抑制剂,也称为 gliptins,是口服抗糖尿病药物的一类.
- 这些药物调节胰岛素和葡萄糖分泌,与其他糖尿病治疗相比,降低低血糖的风险.
- 通常,当甲胺和硫尿素在治疗2型糖尿病时不再有效时, Gliptins 被处方.
研究的目的:
- 审查和分析DPP-4抑制剂的各种分析和生物分析方法.
- 涵盖用于 Gliptin 分析的光谱,色谱和连线技术.
- 提供一个全面的资源,用于量化和估计DPP-4抑制剂在不同的矩阵.
主要方法:
- 进行了系统的文献审查,以收集现有研究.
- 为了收集数据,使用了ScienceDirect和PubMed等数据库.
- 一个流程图说明了文献选择过程的清晰度.
主要成果:
- 染色学技术主要用于DPP-4抑制剂分析.
- 常见的移动相包括乙二,甲醇和缓冲溶液.
- 这些溶剂可能会降解高性能液体染色学 (HPLC) 柱和设备.
结论:
- 本综述是研究人员和医疗保健专业人员分析DPP-4抑制剂的宝贵资源.
- 存在一个差距,因为没有先前的审查涵盖了所有DPP-4抑制剂.
- 未来的研究应该探索用于DPP-4抑制剂分析的环保溶剂,以减轻设备退化.
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