孕期梅毒和不良分娩结果:巴西全国纵向研究
Helena Benes Matos da Silva1,2, Rita de Cássia Ribeiro-Silva1,2, Elzo Pereira Pinto Junior2
1School of Nutrition, Federal University of Bahia, Salvador, Brazil.
概括
孕期梅毒显著增加了不良分娩结果的风险,包括低出生体重和早产. 早期查和治疗对于预防新生儿出现这些并发症至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 孕产妇和儿童的健康
背景情况:
- 梅毒是一种可预防的性传播感染,对母亲和胎儿的健康有重大影响.
- 未经治疗的孕期梅毒会带来不良分娩结果的重大风险.
研究的目的:
- 评估怀孕期间梅毒与不良分娩结果之间的关联.
- 评估VDRL标位,治疗状态和产前护理对这些结果的影响.
主要方法:
- 长度研究使用链接的巴西国家活产信息系统 (SINASC) 和可通报疾病信息系统 (SINAN) 数据 (2011-2017).
- 使用了描述性统计和物流回归分析.
- 研究协议由巴伊亚联邦大学集体健康研究所的研究伦理委员会批准.
主要成果:
- 总共分析了17,930,817例活产;其中155,214例 (8.7/1000例) 涉及患有梅毒的怀孕.
- 孕产妇梅毒与低出生体重 (aOR1.88),怀孕年龄相比较小 (aOR1.53) 和早产 (aOR1.35) 的几率增加有关.
- 对于较高的VDRL标位 (≥64),未经治疗的梅毒和少于六次产前预约,观察到更高的不良结果几率.
结论:
- 孕期梅毒与不利的出生结果密切相关.
- 较高的VDRL标位,缺乏治疗和不充分的产前护理加剧了这些风险.
- 强调在怀孕期间有效查和及时治疗梅毒的必要性.
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