在婴儿期持续摄入牛奶蛋白可能会促进素特异性IgG4的产生
Tetsuhiro Sakihara1, Kenta Otsuji2, Yohei Arakaki3
1Department of Pediatrics, Heartlife Hospital, Okinawa, Japan.
概括
在母乳养的婴儿中,持续摄入牛奶配方 (CMF) 可能会增加素特异性IgG4的产生. 这一发现对于了解敏感婴儿的牛奶过敏发展至关重要.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
背景情况:
- 早期牛奶配方 (CMF) 的引入和停止可能会增加母乳养婴儿的过敏风险.
- 关于持续摄入CMF对牛奶蛋白特异性免疫球蛋白水平的影响的数据有限.
研究的目的:
- 调查持续摄入CMF与牛奶敏感婴儿免疫球蛋白产生的关系.
- 分析不同CMF消费模式的婴儿的特定免疫球蛋白标位.
主要方法:
- 一个日本出生队列随机对照试验的子组分析.
- 包括在出生后3天内摄入CMF的婴儿,并在6个月后对牛奶进行皮肤刺伤测试,结果呈阳性.
- 在6个月以下的CMF持续和停产组之间,对母牛奶特异性IgE,素特异性IgE和素特异性IgG4的中位数比较.
主要成果:
- 持续使用CMF的组与停止使用的组相比,牛奶特异性IgE的中位数显著较低 (P = .0008).
- 两组之间素特异性IgE水平没有显著差异 (P = .51).
- 持续使用CMF的组与停止使用组相比,表现出素特异性IgG4的中位数显著更高 (P < .0001).
结论:
- 持续摄入牛奶配方奶粉可能会促进牛奶敏感婴儿的素特异性IgG4的产生.
- 这表明,持续摄入CMF在调节对牛奶蛋白质的免疫反应方面可能发挥作用.
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