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在绝经后的女性中,肠道微生物有所不同,它们对果做出反应,以保持部骨矿物质密度
Abigayle M R Simpson1, Mary Jane De Souza2, Janhavi Damani3
1Department of Agronomy, Purdue University, West Lafayette, IN, United States.
Frontiers in nutrition
|May 6, 2024
概括
某些肠道微生物增强了在绝经后妇女的骨矿物质密度 (BMD) 的益处. 这一发现支持个性化的营养策略,以改善骨健康.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 骨生理学 骨生理学
背景情况:
- 富含的食物,如,可以改善骨矿物质密度 (BMD).
- 对于骨损伤的果消费的个人反应各不相同.
- 肠道微生物组和免疫反应在调解这些影响中的作用尚未完全理解.
研究的目的:
- 调查肠道微生物组组成,免疫反应和梅在绝经后妇女的骨保护作用之间的关系.
- 为了确定特定的微生物和免疫学因素,与积极的骨质量变化相关,以应对果消费.
主要方法:
- 对一项为期12个月的随机对照试验进行后期分析,该试验涉及每天消费50-100克果.
- 将参与者分为响应者和不响应者,根据关节骨总体变化进行分类.
- 分析身体组成,BMD (DXA扫描),免疫标记 (免疫测试,流动细胞计),类代谢物 (UHPLC-MS) 和便微生物群 (16S rRNA测序).
主要成果:
- 与非响应者相比,响应者表现出明显较低的抗炎标志物 (IL-1β,TNF-α) 水平.
- 在干预前和干预后,在响应者和非响应者之间观察到肠道微生物群α和β多样性的明显差异.
- 响应者显示,奥斯基洛斯皮拉属和拉克诺斯皮拉属细菌家族的丰富性更高.
结论:
- 肠道微生物组的组成与在绝经后妇女的骨髓损伤 (BMD) 中对果消费的差异反应有关.
- 特定的肠道细菌,如奥斯基洛斯皮拉属和拉克诺斯皮拉属,可能在调解的骨保护作用方面发挥作用.
- 这些发现表明了精确营养方法的潜力,根据个体的微生物组概况量身定制的摄入量,以优化BMD益处.
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