一种新的诺米图集体组成和炎症营养标志物,用于预测患有粘性小肠阻塞的患者的术后并发症
Zhibo Wang1, Baoying Sun2, Yimiao Yu3
1Department of Gastroenterological Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
Frontiers in nutrition
|May 6, 2024
概括
一种新的诺莫图谱预测了粘性小肠阻塞 (ASBO) 患者的术后并发症,使用CT身体组成和炎症标志物. 这种工具有助于临床决策,以获得更好的患者结果.
科学领域:
- 放射学和成像学 放射学和成像学
- 手术瘤学手术瘤学
- 营养科学 营养科学
背景情况:
- 粘性小肠阻塞 (ASBO) 的术后并发症增加了医疗费用和住院时间.
- 准确预测这些并发症对于有效的患者管理至关重要.
- 当前的预测模型可能无法完全整合多样化的患者数据.
研究的目的:
- 开发和验证ASBO患者手术后并发症的预测性名谱.
- 整合计算机断层扫描 (CT) 身体组成数据与炎症营养标志物.
- 加强ASBO管理的临床决策.
主要方法:
- 190名ASBO患者的队列被分为训练 (n=133) 和内部验证 (n=57) 组,外部队列为52名患者.
- 进行了基于CT的身体组成分析,并记录了基线特征,包括炎症营养标志物.
- 多变量回归确定了风险因素,并使用一致性指数和ROC曲线分析构建和验证了预测性名录.
主要成果:
- 术后并发症发生在42-49%的患者中.
- 营养风险评分 (NRS),肠道窒息,骨肌肉指数 (SMI),皮下脂肪指数 (SFI),中性细胞-淋巴细胞比率 (NLR) 和淋巴细胞-单细胞比率 (LMR) 是独立的预测因素.
- 诺米图表表现出高预测性能,AUC在验证集中从0.831到0.886不等,显示出良好的校准和临床效用.
结论:
- 一个经过验证的纳米图,包括CT体质组成和炎症-营养指数,可以准确预测ASBO的术后并发症.
- 这种工具可以显著帮助临床医生预测风险并优化患者护理.
- 该名ogram代表了ASBO管理的有价值的进步.
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