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与骨髓介质干细胞相结合的Interceed改善了子宫内粘附的子宫内膜受体性

Yuan Yang^1,2, Yidan Wang², Yi Huang¹

¹Reproductive Medicine Center, The First Hospital of Lanzhou University, Lanzhou 730000, China.

Regenerative therapy

|May 6, 2024

概括

将骨髓介质干细胞 (BMSC) 与Interceed疗法结合起来,可以有效地治疗大鼠的子宫内粘附 (IUA). 这种方法可以增强子宫内膜的厚度,促进腺体再生和血管生成,改善子宫的受容性并增加妊娠率.

科学领域:

生殖生物学生殖生物学
干细胞疗法是一种干细胞疗法.
妇科研究研究妇科研究

背景情况:

子宫内粘附 (IUA) 损害子宫内膜受体和生育能力.
目前用于IUA的治疗方法在恢复子宫内膜功能方面存在局限性.
骨髓介质干细胞 (BMSCs) 显示了组织再生的潜力.

研究的目的:

评估自身骨髓介质干细胞 (BMSCs) 与Interceed结合用于治疗子宫内粘附 (IUA) 的疗效.
评估这种联合治疗对子宫内膜接受度和怀孕率在老鼠模型中的影响.

主要方法:

通过机械伤害在老鼠身上建立了一个IUA模型.
鼠被用盐水,Interceed,BMSC或BMSC和Interceed的组合治疗.
分析了LIF,整蛋白αvβ3和VEGF的子宫内膜组织学 (HE染色),纤维化 (马森染色),微血管密度 (IHC) 和基因/蛋白质表达 (qRT-PCR,西部斑).
评估了生殖结果.

主要成果:

与IUA模型相比,BMSCs和BMSCs + Interceed疗法显著增加了子宫内膜腺的数量,厚度和微血管密度.
结合BMSCs + Interceed治疗组显示LIF,整合素αvβ3和VEGF的表达显著增加.
在BMSCs和BMSCs + Interceed组中,怀孕率明显高于对照组和Interceed组.

结论:

结合BMSCs和Interceed疗法有效地修复了IUA损坏的子宫内膜.
这种治疗促进子宫内膜血管生成,并改善子宫的受容性.
结合疗法显著增加了IUA的老鼠的怀孕率.

关键词:

这就是BMSCs.宫内膜的受体性宫内膜的受体性干预干预干预干预干预干预干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰干扰宫内粘附在子宫内粘附.

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