在上空消化道的前恶性病变的演变的分子特征
Axel Lechner1, Jörg Kumbrink2, Christoph Walz2
1Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-Universität (LMU) Munich University Hospital, Munich, Germany.
Frontiers in oncology
|May 6, 2024
概括
基因组和免疫变化发生在头部和部状细胞癌 (HNSCC) 演变的早期. 了解癌症前期病变中的这些早期变化,可以帮助预测和预防癌症的进展.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 免疫学 免疫学 免疫学
背景情况:
- 由于早期复发和转移,头支状细胞癌 (HNSCC) 的预后不佳.
- 虽然HNSCC源于先前恶性领域的基因改造细胞,但预测进展仍然是一个挑战.
- 了解分子机制对于降低HNSCC发病率和死亡率至关重要.
研究的目的:
- 分析HNSCC中正常,前恶性和癌症组织的基因组和免疫微环境.
- 在p16阴性病例中确定驱动HNSCC进展的早期分子事件.
主要方法:
- 针对性下一代测序 (161个基因) 和浅层全基因组测序在匹配的组织样本上进行.
- 纳米链泛癌免疫面板用于分析免疫微环境.
- 样本包括7名患者的正常状组织,前恶性病变和原发性/复发性瘤.
主要成果:
- 最常发生突变的基因是TP53和NOTCH1.
- 基因组不稳定性从正常的粘膜增加到高度的发育不稳定,基因组的重新排列类似于侵入性癌症.
- 干扰素通路基因在发育不良早期被上调,SPINK5甚至在低度病变中也被下调.
结论:
- 基因组变化和异常免疫基因表达在上空消化道瘤进化的早期是可以检测到的.
- 这些早期变化为治疗干预提供了潜在的目标,以防止HNSCC的进展.
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