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Digital Microfluidics for Automated Proteomic Processing
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活动矩阵数字微流体设计用于现场可编程高通量数字化液体处理.

Dongping Wang1, Kai Jin1, Jiajian Ji1,2

  • 1CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P.R. China.

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概括

我们使用薄膜晶体管 (TFT) 技术开发了一种可编程现场滴滴阵列 (FPDA),用于生命科学研究,精确控制数千个微小的液滴.

关键词:
化学 化学 化学流体学是一种流体学.物理 物理学 物理

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科学领域:

  • 微流体学 微流体学
  • 数字微流体学数字微流体学
  • 薄膜电子产品 薄膜电子产品

背景情况:

  • 数字液体处理对于先进的生命科学至关重要.
  • 现有的系统在滴滴大小和控制方面存在局限性.

研究的目的:

  • 引入一种基于活性矩阵薄膜晶体管 (TFT) 的新型数字微流体系统.
  • 为了证明精确的,可编程的操作成千上万的液滴.

主要方法:

  • 开发一个具有256x256像素的可编程字段滴滴阵列 (FPDA).
  • 使用一种新的TFT设备和电路设计,用于单像素滴滴控制.
  • 实现了0.5nL滴滴的操纵,比以前报告的要小得多.

主要成果:

  • 同时操纵成千上万个可定位的液滴.
  • 在单个像素水平上展示了程序控制.
  • 实现了0.5nL的最小滴量,这是两次数的改善.

结论:

  • 该FPDA系统展示了薄膜电子在数字液体处理中的潜力.
  • 这项技术可以创建可编程的芯片实验室设备.
  • 预计生命科学研究将取得重大进展.