信使RNA表达与乳腺癌临床病理特征之间的相关性:系统性审查
Xue Hu1, Wanying Xing1, Wan Wang1
1Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China.
Journal of Cancer
|May 6, 2024
概括
使者RNA (mRNA) 表达与乳腺癌分级和分期有显著的关联. 虽然与瘤大小相关,但它与乳腺癌患者的月经状况没有联系.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 研究信使RNA (mRNA) 表达和乳腺癌 (BC) 的临床病理特征之间的关系.
- 了解乳腺癌进展及其临床表现的分子基础.
研究的目的:
- 进行元分析以确定乳腺癌患者mRNA表达和各种临床病理特征之间的相关性.
- 提供对乳腺癌预后和治疗的潜在生物标志物的见解.
主要方法:
- 在主要的英语数据库 (PubMed,Web of Science,Embase,Cochrane Library) 进行系统的文献搜索,截至2023年12月.
- 在选择相关研究时采用了包含和排除标准.
- 使用Revman5.3软件进行的数据提取和元分析.
主要成果:
- 对涉及969名患者的5项研究的分析显示,mRNA表达与乳腺癌分级 (OR=0.11,P<0.0001) 和分期 (OR=0.19,P=0.008) 之间存在显著的关联.
- 确定了mRNA表达和瘤大小 (OR=0.48,P=0.05) 之间的相关性.
- 在乳腺癌患者的mRNA表达和月经状况之间没有发现显著的相关性 (OR=0.63,P=0.38).
结论:
- mRNA表达是与乳腺癌分级,阶段和瘤大小相关的重要因素.
- 对mRNA表达模式的进一步研究可能为乳腺癌提供有价值的预后和治疗点.
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