在COVID-19患者中,心上脂肪组织和心肌损伤之间的相关性
Tianhong Su1, Bincheng Zhong2, Chao Tang1
1Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Frontiers in physiology
|May 6, 2024
概括
在COVID-19患者中,心上脂肪组织 (EAT) 体积的增加与心肌损伤的增加有关. 在这些人中,EAT是心脏损伤的独立预测因子,突出其临床意义.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 生物标志物 生物标志物
背景情况:
- 心肌损伤是COVID-19的一个常见并发症.
- 心脂肪组织 (EAT) 是一个已知的心血管风险因素.
- EAT与COVID-19相关的心肌损伤之间的关联需要进一步调查.
研究的目的:
- 调查COVID-19患者心上脂肪组织 (EAT) 体积和心肌损伤之间的相关性.
- 在COVID-19的背景下,确定EAT作为心脏损伤的潜在独立预测因子.
主要方法:
- 一项涉及COVID-19患者的队列研究,从2022年12月到2023年1月.
- 患者被分为两组:没有心肌损伤的患者 (A组,n=152) 和心肌损伤的患者 (B组,n=212).
- 分析包括心肌生物标志物,脂质概况,炎症标志物和EAT体积.
主要成果:
- 在年龄,TC,CRP,Cr,BUN,LDL-C,IL-6,BNP,LVEF和EAT (p <0.05) 组之间观察到显著差异.
- EAT体积与IL-6,LDL-C,cTnI和CRP显示出正相关性 (p <0.05).
- 较高的EAT体积与COVID-19患者心肌损伤的可能性更高有关,EAT被确定为独立的风险因素.
结论:
- 心上脂肪组织 (EAT) 体积增加是COVID-19患者心肌损伤的重要危险因素.
- EAT作为心脏损伤的独立预测器,表明其在风险分层和管理中的潜在作用.
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