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甲福明辅助治疗对1型糖尿病印度青少年心脏代谢参数的影响:随机对照试验
Shruti Mondkar1, Sukeshini Khandagale2, Nikhil Shah1
1Department of Pediatric Endocrinology & Growth, Hirabai Cowasji Jehangir Medical Research Institute (HCJMRI), Pune, India.
Frontiers in clinical diabetes and healthcare
|May 6, 2024
概括
在1型糖尿病 (T1D) 的亚洲印第安青少年中,将甲福明添加到胰岛素治疗中改善了血糖控制和胰岛素敏感性. 这种干预措施也对心脏代谢参数和身体成分有好处,具有良好的安全性.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 儿童糖尿病管理管理
背景情况:
- 胰岛素抵抗在1型糖尿病 (T1D) 中越来越普遍,加速了微血管并发症.
- 亚洲印第安人面临患双重糖尿病的风险更高.
- 了解这种人群中T1D的干预措施至关重要.
研究的目的:
- 为了研究添加美特福林到标准胰岛素治疗的效果.
- 评估对血糖控制,胰岛素敏感性,心脏代谢参数和身体组成的影响.
- 为了评估印度青少年T1D的结果.
主要方法:
- 一个为期9个月的随机对照试验,涉及82名患有T1D的青少年 (年龄10-19岁,HbA1c>8%).
- 参与者被随机分配给接受甲福明或安慰剂,根据年龄,性别和糖尿病持续时间进行匹配.
- 血糖控制,胰岛素敏感性,脂质和身体组成的评估在基线,3个月和9个月进行.
主要成果:
- 与安慰剂相比,美特福林显著降低了HbA1c (0.8%的降低) 并改善了血糖变异性.
- 虽然胰岛素敏感度得分没有显示Metformin的变化,但安慰剂恶化.
- 甲胺减轻了与安慰剂一起观察到的LDL-C,总胆固醇,甘油三和心动脉内心介质厚度的不良变化;它还防止了体重和BMI的增加.
结论:
- 亚裔印度裔青少年患有T1D的辅助甲福明治疗对血糖控制和可变性有好处.
- 这项研究强调了对胰岛素敏感性,脂质概况,血管功能和身体成分的积极影响.
- 在这个队列中,在9个月的时间里,甲胺表现出良好的安全性.
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