亲大脑衍生神经营养因子 (BDNF),但不成熟的BDNF,在人类骨肌肉中表达:对运动诱导的神经可塑性的影响
Sebastian Edman1,2, Oscar Horwath1, Thibaux Van der Stede3,4
1Åstrand Laboratory, Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.
Function (Oxford, England)
|May 6, 2024
概括
运动增加了骨肌肉和血中的亲脑衍生神经营养因子 (亲BDNF). 这种蛋白质,特别是在I型纤维中,有助于循环成熟的BDNF (mBDNF) 水平,影响神经健康.
科学领域:
- 运动生理学 运动生理学
- 神经科学是一个神经科学.
- 分子生物学分子生物学
背景情况:
- 运动可以增强大脑的可塑性,部分是通过成熟的大脑衍生神经营养因子 (mBDNF).
- 亲BDNF在人类骨肌中的功能及其在BDNF代谢中的作用仍然不清楚.
研究的目的:
- 量化人类骨肌肉和血中的亲BDNF和mBDNF表达.
- 为了研究急性运动,乳酸注入和禁食对这些异构体的影响.
主要方法:
- 使用免疫栓塞,ELISA,免疫组织化学和qPCR对亲BDNF和mBDNF的分析.
- 休息时,经过急性运动 (含/不含乳酸) 和经过3天禁食后进行的测量.
主要成果:
- 在骨肌肉 (特别是I型纤维) 中检测到pro-BDNF,而mBDNF则没有.
- 运动增加了血mBDNF和亲BDNF,以及肌肉亲BDNF.
- 在运动期间注入乳酸盐显著增加了血mBDNF;禁食略微增加了血亲BDNF.
结论:
- 亲BDNF在人类骨肌肉中丰富,并且随着运动而增加.
- 运动诱导的mBDNF增加可能部分源于骨肌肉的亲BDNF释放和裂变.
- 这些发现与阿尔茨海默氏症,抑郁症和ALS等神经系统疾病有关.
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