在12周内从60%降至5%:特拉斯图祖马布诱导的左心室喷射分数下降
Qianjun Pan1, Rui Zhao2, Suzette Graham-Hill3
1Internal Medicine, SUNY (State University of New York) Downstate Health Sciences University, Brooklyn, USA.
Cureus
|May 6, 2024
概括
特拉斯图祖马布在HER2阳性乳腺癌患者中可能导致罕见但严重的心力衰竭,即使在治疗了数年后也会发生这种情况. 早期发现和管理对于改善结果至关重要.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 心血管毒理学心血管毒理学
- 乳腺癌治疗方法 乳腺癌治疗方法
背景情况:
- 特拉斯图祖马布是治疗HER2阳性乳腺癌的第一线疗法,但与心脏毒性有关.
- 特拉斯图祖马布诱导的心脏毒性通常表现为左心室喷射率 (LVEF) 的可逆性减少.
- 由于trastuzumab引起的急性不补偿性心力衰竭是罕见的,发生在大约0.5%的患者中.
更多相关视频
12:45Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
10.5K
09:05Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
19.6K
相关概念视频
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
