与伤寒和DTP疫苗接种相关的针对严重COVID-19的非特异性保护
Ramon A Juste1, Kalliopi Vrotsou2,3,4, Maider Mateo-Abad3,4
1NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Parque Científico y Tecnológico de Bizkaia, P812, E-48160 Derio, Spain.
训练免疫力 (TRAIM) 从伤寒热病疫苗 (TFV) 和 diphtheria-tetanus-pertussis (DTP) 疫苗接种略有增加了感染率,但显著减少了COVID-19住院治疗和死亡. 这些发现支持TRAIM对严重的COVID-19结果的保护作用.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 训练免疫 (TRAIM) 描述了刺激后增强的非特异性免疫反应.
- 之前接种疫苗对COVID-19结果的影响是积极研究的一个领域.
研究的目的:
- 为了研究伤寒疫苗 (TFV) 和白喉疹咳 (DTP) 疫苗对COVID-19感染,住院和死亡率的影响.
- 评估训练免疫 (TRAIM) 在调节COVID-19严重性的作用.
主要方法:
- 追溯研究分析了COVID-19疫苗接种推出前后巴斯克国家 (西班牙) 的数据.
- 在疫情前四年内接种TFV或DTP的受试者与未接种疫苗的对照者之间比较COVID-19结果.
- 对感染,住院和死亡比例和几率比率 (OR) 的统计分析.
主要成果:
- 接种TFV和DTP疫苗与SARS-CoV-2感染率略有增加有关 (OR分别为1.505和1.633).
- 然而,TFV和DTP疫苗接种显著减少了COVID-19相关的住院治疗 (ORs 0.295和0.667) 和死亡 (ORs 0.016和0.212).
- 住院治疗的减少率从32.44%降至69.74%,死亡率从78.52%降至98.38%.
结论:
- 这项研究支持由TFV和DTP疫苗接种诱导的训练免疫 (TRAIM) 的概念.
- 之前用TFV和DTP接种疫苗显示出强烈的保护作用,防止COVID-19的严重后果,包括住院和死亡.
- 对于严重的COVID-19来说,TRAIM可能提供了一个非特定的保护机制.
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