在急性中风患者中,白质过强度和3个月后的结果之间的相关性中性别差异
Junli Ren1,2, Xia Zhang3, Haobo Xie2
1Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Heliyon
|May 6, 2024
概括
白质超强度 (WMH) 的严重程度预测了中风的不良结果,特别是在女性中. 在女性中,较高的WMH严重程度显著增加了急性缺血性中风后不良结果的风险.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 脑卒中医学 脑卒中医学
背景情况:
- 白质超强度 (WMH) 与中风的不良结果有关.
- 性别对WMH严重程度和中风结果之间的关联的影响仍未得到充分研究.
研究的目的:
- 调查潜在的性别差异在WMH严重程度和中风结果之间的关系.
- 为了确定WMH严重程度是否对中风预后有性别特异性的影响.
主要方法:
- 对449名急性缺血性中风 (AIS) 患者进行了回顾性分析,这些患者接受了静脉输血栓溶解治疗.
- 使用Fazekas尺度评估WMH严重程度.
- 多变量回归分析分别对男性和女性进行.
主要成果:
- 在女性中,WMH在最高三位数 (Fazekas>3) 的严重程度显示,与最低三位数 (Fazekas <2) 相比,不良结果的风险增加了5.334倍 (p-trend=0.026).
- 中度至重度WMH (Fazekas 3-6) 与女性不至轻度WMH (Fazekas 0-2) (p=0.027) 相比,与女性不至轻度WMH (Fazekas 3-6) 的不良结果风险增加了3.391倍.
结论:
- 在女性中,中风后果风险与WMH严重程度成比例增加.
- 在中风风险分层方面,WMH严重程度可能具有性别特定的预测价值.
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